Broad-spectrum coronavirus antiviral drug discovery
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چکیده
منابع مشابه
Antiviral drug discovery: broad-spectrum drugs from nature.
Covering: up to April 2014. The development of drugs with broad-spectrum antiviral activities is a long pursued goal in drug discovery. It has been shown that blocking co-opted host-factors abrogates the replication of many viruses, yet the development of such host-targeting drugs has been met with scepticism mainly due to toxicity issues and poor translation to in vivo models. With the advent ...
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Development of highly effective, broad-spectrum antiviral agents is the major objective shared by the fields of virology and pharmaceutics. Antiviral drug development has focused on targeting viral entry and replication, as well as modulating cellular defense system. High throughput screening of molecules, genetic engineering of peptides, and functional screening of agents have identified promi...
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Mucus is a porous biopolymer matrix that coats all wet epithelia in the human body and serves as the first line of defense against many pathogenic bacteria and viruses. However, under certain conditions viruses are able to penetrate this infection barrier, which compromises the protective function of native mucus. Here, we find that isolated porcine gastric mucin polymers, key structural compon...
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This review is an attempt to portray the discovery and development of ethnomedicine and its phytophores against some important viral diseases from galenical to genomical period. Natural resource, particularly the plants and animals have been the basis of traditional treatment since the dawn of human civilization and the modern medicine (Allopathy) has gradually developed, over the years, by sci...
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ژورنال
عنوان ژورنال: Expert Opinion on Drug Discovery
سال: 2019
ISSN: 1746-0441,1746-045X
DOI: 10.1080/17460441.2019.1581171